Dapsone gel 5% vs 7.5%: concentration is not exposure

Every row cites its source. Where a cell reflects our own reading of the evidence rather than an external source, the row says so.

The counterintuitive tier table: the stronger gel, used once daily, puts less dapsone in the blood than the weaker gel used twice daily.

Dapsone gel 5% vs 7.5%: concentration is not exposure
Aspect	Gel 5%	Gel 7.5%	Source
Schedule	Twice daily, pea-sized amount to affected areas	Once daily, pea-sized amount to the entire face	source
Approval	NDA 021794, July 7, 2005	NDA 207154, February 24, 2016	source
Systemic exposure	AUC 415 ng.h/mL at day 14 (BID)	AUC 282 ng.h/mL at steady state; 25 to 40% lower daily exposure than 5% BID in the comparative study	source
Pivotal results	GAAS success 42% vs 32% and 35% vs 28%	GAAS success 29.9% vs 21.2% and 29.8% vs 20.9% (different trial populations; not head-to-head)	source
Age floor	Trials enrolled 12 and up	Indicated 9 years and older	source
Packaging	30, 60, 90 g laminate tubes	30, 60, 90 g airless pumps	source